Violence and schizophrenia: clozapine as a specific antiaggressive agent.
P. Buckley, J. Bartell, K. Donenwirth, S. Lee, F. Torigoe and S. C. Schulz,
Bull. Amer. Acad. Psychiatry & the Law
23(4): 607-11, 1995.
Pharmacological management of persistent aggression in patients with schizophrenia is a difficult
clinical dilemma. Clozapine has been shown to be an effective agent in this regard. This study sought
to compare the symptomatic response on the Brief Psychiatric Rating Scale (BPRS) between hostile
schizophrenic patients and patients without aggression. While dramatic improvements were evident
in aggression, both groups were indistinguishable with respect to BPRS response. These results
suggest that clozapine may have a selective antiaggressive effect.