A comparison of treatment of paraphilias with three serotonin reuptake inhibitors: a
D. M. Greenberg, J. M. Bradford, S. Curry and O. R. A,
Bull. Amer. Acad. Psychiatry & the Law
24(4): 525-32, 1996.
Treatment of the paraphilic disorders using behavioral, cognitive, pharmacological, and social
interventions has been shown to have limited success with poorly motivated or noncompliant
patients. Researchers have speculated on the role of the serotonergic system in the paraphilic
disorders. Recent anecdotal studies have reported successful results with the selective serotonin
reuptake inhibitors (SSRIs) in the treatment of the paraphilic disorders. This retrospective study
evaluates and compares the effectiveness of three SSRIs in a group of paraphilics (N = 58). The
individual effectiveness of fluvoxamine, fluoxetine, and sertraline were examined and compared.
Results found that the severity of fantasies decreased and that there were no significant differences
in the reported efficacy between fluvoxamine, fluoxetine, and sertraline. Although double blind
placebo crossover studies are still needed to assess the efficacy of these agents, this study further
supports the growing body of literature on the potential use of these drugs in the treatment of the